Methanamine, N-methoxy-, hydrochloride (1:1) → 3-(3-Bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide

HRID 1617534Notes

Reaction equation

HRID 1617534 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])[CH2:9][C:10](O)=[O:11])[CH:5]=[CH:6][CH:7]=1.Cl.[CH3:21][NH:22][O:23][CH3:24]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])[CH2:9][C:10]([N:22]([O:23][CH3:24])[CH3:21])=[O:11])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 666668093-(3-Bromo-phenyl)-3-o-tolyl-propionic acid

Product 1

HCID 866609653-(3-Bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide

Procedure

In analogy to example 74, step 4, from 3-(3-bromo-phenyl)-3-o-tolyl-propionic acid and N,O-dimethylhydroxylamine hydrochloride was prepared the title compound as a white solid, mp 89° C., MS (ESI+): m/z=362.07 ([M+H]+, 1 Br).

Sources & evidence

ORD record
ord-4bc9220772a24534bf78a8a2a46d4144
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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