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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1617550Generated: October 31, 2026

Hydroxyamine hydrochloride → 2-[[3-[3-[(3E)-3-hydroxyimino-1-(2-methylphenyl)-3-(2-methyl-4-pyridinyl)propyl]phenyl]benzoyl]amino]acetic acid

https://huagongshe.com/reaction/1617550

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydroxyamine hydrochlorideHCID 443297—
ReactantSodium BicarbonateHCID 516892—
Reactant({3'-[3-(2-Methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-3-carbonyl}-amino)-acetic acidHCID 67015501—
Product2-[[3-[3-[(3E)-3-hydroxyimino-1-(2-methylphenyl)-3-(2-methyl-4-pyridinyl)propyl]phenyl]benzoyl]amino]acetic acidHCID 136385747—

Reaction Steps

In analogy to example 74, step 4, from ({3′-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-3-carbonyl}-amino)-acetic acid and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound which precipitated as a white solid on work up, MS (ESI−): m/z=506.2 ([M−H]−).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765730B2
Source datasetuspto-grants-2014_07
ORD IDord-4c7ea2430259411e942e59753bbd3d9f
Source noteuspto-grants-2014_07