HRID1617550

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID443297

未命名化合物

HCID516892

Sodium Bicarbonate

CHNaO3

结构：Cc1cc(C(=O)CC(c2cccc(-c3cccc(C(=O)NCC(=O)O)c3)c2)c2ccccc2C)ccn1

HCID67015501

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(/C(CC(c2cccc(-c3cccc(C(=O)NCC(=O)O)c3)c2)c2ccccc2C)=N/O)ccn1

HCID136385747

未命名化合物

PROCEDURE

实验过程

In analogy to example 74, step 4, from ({3′-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-3-carbonyl}-amino)-acetic acid and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound which precipitated as a white solid on work up, MS (ESI−): m/z=506.2 ([M−H]−).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4c7ea2430259411e942e59753bbd3d9f
来源数据集: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08765730B2
来源说明: uspto-grants-2014_07

反应 SMILES

[CH3:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH2:9][CH:10]([C:18]2[CH:19]=[C:20]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([NH:32][CH2:33][C:34]([OH:36])=[O:35])=[O:31])[CH:25]=3)[CH:21]=[CH:22][CH:23]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH:5]=[CH:4][N:3]=1.Cl.[NH2:39][OH:40].C([O-])(O)=O.[Na+]>>[OH:40]/[N:39]=[C:8](/[C:6]1[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=1)\[CH2:9][CH:10]([C:18]1[CH:19]=[C:20]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([NH:32][CH2:33][C:34]([OH:36])=[O:35])=[O:31])[CH:25]=2)[CH:21]=[CH:22][CH:23]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17]