2-Fluoro-4-iodo-6-methylpyridine → 3-(3-Bromo-phenyl)-1-(2-fluoro-6-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one

HRID 1617566Notes

Reaction equation

HRID 1617566 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10](N(OC)C)=[O:11])[CH:5]=[CH:6][CH:7]=1.[F:23][C:24]1[CH:29]=[C:28](I)[CH:27]=[C:26]([CH3:31])[N:25]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10]([C:28]2[CH:27]=[C:26]([CH3:31])[N:25]=[C:24]([F:23])[CH:29]=2)=[O:11])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 447547522-Fluoro-4-iodo-6-methylpyridineHCID 86660965HCID 86660965, compound

Product 1

HCID 666661973-(3-Bromo-phenyl)-1-(2-fluoro-6-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one

Procedure

In analogy to example 74, step 5, from 3-(3-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 98, step 4) and 2-fluoro-4-iodo-6-picoline (CAS RN: [884494-45-5]) was prepared the title compound as colorless oil, MS (ESI+): m/z=412.1 ([M+H]+, 1Br).

Sources & evidence

ORD record
ord-e616a5cf24eb4573b87d2e24d899d893
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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