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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1617566Generated: October 25, 2026

2-Fluoro-4-iodo-6-methylpyridine → 3-(3-Bromo-phenyl)-1-(2-fluoro-6-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one

https://huagongshe.com/reaction/1617566

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-4-iodo-6-methylpyridineHCID 44754752—
ReactantHCID 86660965HCID 86660965—
Product3-(3-Bromo-phenyl)-1-(2-fluoro-6-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-oneHCID 66666197—

Reaction Steps

In analogy to example 74, step 5, from 3-(3-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 98, step 4) and 2-fluoro-4-iodo-6-picoline (CAS RN: [884494-45-5]) was prepared the title compound as colorless oil, MS (ESI+): m/z=412.1 ([M+H]+, 1Br).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765730B2
Source datasetuspto-grants-2014_07
ORD IDord-e616a5cf24eb4573b87d2e24d899d893
Source noteuspto-grants-2014_07