2-Fluoro-4-iodo-5-methylpyridine → 3-(4-Bromo-phenyl)-1-(2-fluoro-5-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one

HRID 1617570Notes

Reaction equation

HRID 1617570 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10](N(OC)C)=[O:11])=[CH:4][CH:3]=1.[F:23][C:24]1[CH:29]=[C:28](I)[C:27]([CH3:31])=[CH:26][N:25]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10]([C:28]2[C:27]([CH3:31])=[CH:26][N:25]=[C:24]([F:23])[CH:29]=2)=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 100600522-Fluoro-4-iodo-5-methylpyridineHCID 866609493-(4-Bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide

Product 1

HCID 670155043-(4-Bromo-phenyl)-1-(2-fluoro-5-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one

Procedure

In analogy to example 74, step 5, from 3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 74, step 4) and 2-fluoro-4-iodo-5-picoline (CAS RN: [153034-94-7]) was prepared the title compound as a light yellow oil, MS (ESI−): m/z=410.0558 ([M−H]−, 1Br).

Sources & evidence

ORD record
ord-9d7296b118244a32a8e240bc53215f83
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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