6-Bromoquinoline → 3-(4-Bromo-phenyl)-1-quinolin-6-yl-3-o-tolyl-propan-1-one

HRID 1617571Notes

Reaction equation

HRID 1617571 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10](N(OC)C)=[O:11])=[CH:4][CH:3]=1.Br[C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[N:30]=[CH:29][CH:28]=[CH:27]2>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10]([C:24]2[CH:25]=[C:26]3[C:31](=[CH:32][CH:33]=2)[N:30]=[CH:29][CH:28]=[CH:27]3)=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 792436-BromoquinolineHCID 866609493-(4-Bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide

Product 1

HCID 670155803-(4-Bromo-phenyl)-1-quinolin-6-yl-3-o-tolyl-propan-1-one

Procedure

In analogy to example 74, step 5, from 3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 74, step 4) and 6-bromoquinoline (CAS RN: [5332-25-2]) was prepared the title compound as a yellow oil, MS (ESI+): m/z=430.0791 ([M+H]+, 1Br).

Sources & evidence

ORD record
ord-98b8198722124f7a949005730451f6a6
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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