Benzene, 1-bromo-2-(trifluoromethyl)- → 3-(4-Bromo-phenyl)-2-cyano-3-(2-trifluoromethyl-phenyl)-propionic acid ethyl ester

HRID 1617583Notes

Reaction equation

HRID 1617583 reaction equation
[CH2:1]([O:3][C:4](=[O:16])/[C:5](/[C:14]#[N:15])=[CH:6]/[C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)[CH3:2].Br[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]([F:27])([F:26])[F:25]>>[CH2:1]([O:3][C:4](=[O:16])[CH:5]([C:14]#[N:15])[CH:6]([C:7]1[CH:8]=[CH:9][C:10]([Br:13])=[CH:11][CH:12]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]([F:27])([F:26])[F:25])[CH3:2]

Participants

3

Reactant 2

HCID 9806Benzene, 1-bromo-2-(trifluoromethyl)-HCID 5378084Ethyl 3-(4-bromophenyl)-2-cyanoacrylate

Product 1

HCID 666663383-(4-Bromo-phenyl)-2-cyano-3-(2-trifluoromethyl-phenyl)-propionic acid ethyl ester

Procedure

In analogy to example 74, step 2, from (E)-3-(4-bromo-phenyl)-2-cyano-acrylic acid ethyl ester and 2-bromobenzotrifluoride (CAS RN: [392-83-6]) was prepared the title compound as a brown oil, MS (ESI−): m/z=424.0 ([M−H]−, 1Br).

Sources & evidence

ORD record
ord-c099356cf98c4b21ae54b9dd657773a6
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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