反应详情

温度

80 °C

Iron powder (3 g, 53.4 mmol) and acetic acid (10 mL) were added to a stirred suspension of 4-bromo-2-nitro-1-phenoxybenzene (3.1 g, 9.5 mmol) in water (25 mL) of 60° C. The reaction mixture was heated to 80° C. and stirred for 30 min. After cooling to room temperature the reaction mixture was filtered and extracted with toluene. The toluene solution was washed with water (3×) and brine, dried (Na2SO4) and evaporated to give the crude compound (2.3 g, 87%). Data: (m/z)=264+266 (M+H)+.

1. temperatureAfter cooling to room temperature the reaction mixture
2. filtrationwas filtered
3. extractionextracted with toluene
4. washThe toluene solution was washed with water (3×) and brine
5. dry with materialdried (Na2SO4)
6. customevaporated