Lithium → (R)-4'-(3-(2,6-Dichloropyridin-4-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid

HRID 1617604Notes

Reaction equation

HRID 1617604 reaction equation
CON(C)[C:4](=[O:29])[CH2:5][C@H:6]([C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([OH:28])=[O:27])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH3:13].[Li].[Cl:32][C:33]1[CH:38]=[C:37](I)[CH:36]=[C:35]([Cl:40])[N:34]=1>>[Cl:32][C:33]1[CH:38]=[C:37]([C:4](=[O:29])[CH2:5][C@H:6]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[CH:22][C:23]([C:26]([OH:28])=[O:27])=[CH:24][CH:25]=3)=[CH:16][CH:15]=2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH3:13])[CH:36]=[C:35]([Cl:40])[N:34]=1

Participants

4

Reactant 3

HCID 3028194LithiumHCID 117373932,6-Dichloro-4-iodopyridineHCID 866610084'-[(R)-2-(Methoxy-methyl-carbamoyl)-1-o-tolyl-ethyl]-biphenyl-4-carboxylic acid

Product 1

HCID 86661007(R)-4'-(3-(2,6-Dichloropyridin-4-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid

Procedure

In analogy to example 74, step 5, from (R)-4′-(3-(methoxy(methyl)amino)-3-oxo-1-tolylpropyl)biphenyl-4-carboxylic acid, lithium salt and 2,6-dichloro-4-iodopyridine was prepared the title compound as light brown foam, MS (ESI−): m/z=488.2 ([M−H]−, 1Cl).

Sources & evidence

ORD record
ord-8fbdb9c42dd9446f95d70faf6550014f
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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