HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium → (R)-4'-(3-(2,6-Dichloropyridin-4-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | 2,6-Dichloro-4-iodopyridine | HCID 11737393 | — |
| Reactant | 4'-[(R)-2-(Methoxy-methyl-carbamoyl)-1-o-tolyl-ethyl]-biphenyl-4-carboxylic acid | HCID 86661008 | — |
| Product | (R)-4'-(3-(2,6-Dichloropyridin-4-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid | HCID 86661007 | — |
Reaction Steps
In analogy to example 74, step 5, from (R)-4′-(3-(methoxy(methyl)amino)-3-oxo-1-tolylpropyl)biphenyl-4-carboxylic acid, lithium salt and 2,6-dichloro-4-iodopyridine was prepared the title compound as light brown foam, MS (ESI−): m/z=488.2 ([M−H]−, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-8fbdb9c42dd9446f95d70faf6550014f |
| Source note | uspto-grants-2014_07 |