HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 4-[4-[(1R,3E)-3-(2,6-dichloro-4-pyridinyl)-3-hydroxyimino-1-(2-methylphenyl)propyl]phenyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (R)-4'-(3-(2,6-Dichloropyridin-4-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid | HCID 86661007 | — |
| Product | 4-[4-[(1R,3E)-3-(2,6-dichloro-4-pyridinyl)-3-hydroxyimino-1-(2-methylphenyl)propyl]phenyl]benzoic acid | HCID 136167048 | — |
Reaction Steps
In analogy to example 132, step 6, from (R)-4′-(3-(2,6-dichloropyridin-4-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid and hydroxylamine hydrochloride in the presence of NaHCO3 was prepared the title compound as an off-white foam, MS (ESI−): m/z=503.09 ([M−H]−, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-f398f80a441446e19c49d9b616bb63e0 |
| Source note | uspto-grants-2014_07 |