Methyl iodide → HCID 67015531, compound

HRID 1617653Notes

Reaction equation

HRID 1617653 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:19][CH2:20][CH2:21][C:22]([F:25])([F:24])[F:23])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][CH:17]=2)=[O:11])=[CH:4][CH:3]=1.IC.[C:28](=O)([O-])[O-].[K+].[K+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:19][CH2:20][CH2:21][C:22]([F:25])([F:23])[F:24])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[N:16]([CH3:28])[CH:17]=2)=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 67015599HCID 67015599, compound

Product 1

HCID 67015531HCID 67015531, compound

Procedure

In analogy to example 161, step 1, 5-[3-(4-bromo-phenyl)-7,7,7-trifluoro-heptanoyl]-1H-pyridin-2-one was reacted with iodomethane in the presence of potassium carbonate to give the title compound as a light yellow oil, MS (ESI+): m/z=430.2 [M+H]+.

Sources & evidence

ORD record
ord-ce42b8ebf04540dbad36be3421a8e355
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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