Hydrochloric Acid → HCID 67015607, compound

HRID 1617655Notes

Reaction equation

HRID 1617655 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:20][CH:21]=[CH2:22])[CH2:9][C:10]([C:12]2[CH:13]=[N:14][C:15]([O:18]C)=[CH:16][CH:17]=2)=[O:11])=[CH:4][CH:3]=1.Cl>O1CCOCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH2:20][CH:21]=[CH2:22])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15](=[O:18])[NH:14][CH:13]=2)=[O:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66666134HCID 66666134, compound

Product 1

HCID 67015607HCID 67015607, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to example 162, step 2, 3-(4-bromo-phenyl)-1-(6-methoxy-pyridin-3-yl)-hex-5-en-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as an off-white foam, MS (ESI−): m/z=344.0 [M−H]−.

Sources & evidence

ORD record
ord-b6de874dd9544e88ae74e7b241f636a7
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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