Methyl iodide → HCID 67015578, compound

HRID 1617656Notes

Reaction equation

HRID 1617656 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:19][CH:20]=[CH2:21])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][CH:17]=2)=[O:11])=[CH:4][CH:3]=1.IC.[C:24](=O)([O-])[O-].[K+].[K+]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH2:19][CH:20]=[CH2:21])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[N:16]([CH3:24])[CH:17]=2)=[O:11])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 67015607HCID 67015607, compound

Product 1

HCID 67015578HCID 67015578, compound

Procedure

In analogy to example 161, step 1, 5-[3-(4-bromo-phenyl)-hex-5-enoyl]-1H-pyridin-2-one was reacted with iodomethane in the presence of potassium carbonate to give the title compound as a colorless oil, MS (ESI+): m/z=360.1 [M+H]+.

Sources & evidence

ORD record
ord-b8797cbf492140258b3667540a38af50
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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