Hydrochloric Acid → HCID 66668860, compound

HRID 1617664Notes

Reaction equation

HRID 1617664 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:20]2[CH2:23][CH2:22][CH2:21]2)[CH2:9][C:10]([C:12]2[CH:13]=[N:14][C:15]([O:18]C)=[CH:16][CH:17]=2)=[O:11])=[CH:4][CH:3]=1.Cl>O1CCOCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH:20]2[CH2:23][CH2:22][CH2:21]2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15](=[O:18])[NH:14][CH:13]=2)=[O:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66668522HCID 66668522, compound

Product 1

HCID 66668860HCID 66668860, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to example 162, step 2, 3-(4-bromo-phenyl)-3-cyclobutyl-1-(6-methoxy-pyridin-3-yl)-propan-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give 5-[3-(4-bromo-phenyl)-3-cyclobutyl-propionyl]-1H-pyridin-2-one as a light yellow oil, which was directly subjected to the next step.

Sources & evidence

ORD record
ord-cef0de7a31974531bb8272bd650483b8
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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