Potassium Carbonate → HCID 67015541, compound

HRID 1617675Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:19])[N:16]([CH3:18])[CH:17]=2)=[O:11])=[CH:4][CH:3]=1.[CH3:27][O:28][C:29](=[O:33])[CH2:30]CBr.C(=O)([O-])[O-].[K+].[K+]>>[CH3:27][O:28][C:29](=[O:33])[CH2:30][CH2:18][N:16]1[CH:17]=[C:12]([C:10](=[O:11])[CH2:9][CH:8]([C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH:13]=[CH:14][C:15]1=[O:19]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 76934Methyl 3-bromopropanoate

HCID 666685075-[3-(4-Bromo-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one

Product 1

HCID 67015541HCID 67015541, compound

Procedure

In analogy to example 161, step 1, 5-[3-(4-bromo-phenyl)-3-o-tolyl-propionyl]-1-methyl-1H-pyridin-2-one (example 162, step 3) was reacted with methyl-3-bromopropionate in the presence of potassium carbonate to give the title compound as a colorless foam, MS (ESI+): m/z=482.2 [M+H]+.

Sources & evidence

ORD record: ord-2b08f521c56a41a9a08fe0dd40b338eb
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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