Hydrochloric Acid → HCID 67015628, compound

HRID 1617679Notes

Reaction equation

HRID 1617679 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:20][CH2:21][CH3:22])[CH2:9][C:10]([C:12]2[CH:13]=[N:14][C:15]([O:18]C)=[CH:16][CH:17]=2)=[O:11])=[C:4]([F:23])[CH:3]=1.Cl>O1CCOCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:20][CH2:21][CH3:22])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15](=[O:18])[NH:14][CH:13]=2)=[O:11])=[C:4]([F:23])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66666419HCID 66666419, compound

Product 1

HCID 67015628HCID 67015628, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to example 162, step 2, 3-(4-bromo-2-fluoro-phenyl)-1-(6-methoxy-pyridin-3-yl)-hexan-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as a colorless foam, MS (ESI+): m/z=366.0 [M+H]+.

Sources & evidence

ORD record
ord-50b41f6d4cdc4309a681acda339a75bd
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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