Methyl iodide → HCID 66668978, compound

HRID 1617691Notes

Reaction equation

HRID 1617691 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1)[CH2:9][C:10]([C:12]1[CH:13]=[CH:14][C:15](=[O:18])[NH:16][CH:17]=1)=[O:11].IC.[C:26](=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1)[CH2:9][C:10]([C:12]1[CH:13]=[CH:14][C:15](=[O:18])[N:16]([CH3:26])[CH:17]=1)=[O:11]

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 66669119HCID 66669119, compound

Product 1

HCID 66668978HCID 66668978, compound

Procedure

In analogy to example 161, step 1, 5-[3-(2-chloro-phenyl)-3-cyclopentyl-propionyl]-1H-pyridin-2-one was reacted with iodomethane in the presence of potassium carbonate to give the title compound as a light yellow oil, MS (ESI+): m/z=344.2 [M+H]+.

Sources & evidence

ORD record
ord-94d6501647474a768faa2a440a6cc6c2
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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