Hydrochloric Acid → HCID 66669220, compound

HRID 1617699Notes

Reaction equation

HRID 1617699 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[CH2:9][C:10]([C:12]2[CH:13]=[N:14][C:15]([O:18]C)=[CH:16][CH:17]=2)=[O:11])=[CH:4][CH:3]=1.Cl>O1CCOCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15](=[O:18])[NH:14][CH:13]=2)=[O:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67015592HCID 67015592, compound

Product 1

HCID 66669220HCID 66669220, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to example 162, step 2, 3-(4-bromo-phenyl)-3-(2-chloro-phenyl)-1-(6-methoxy-pyridin-3-yl)-propan-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as an off-white foam, MS (ESI+): m/z=413.9 [M−H]−.

Sources & evidence

ORD record
ord-ca0f8bdc1ddf4a3bbaf6142dbfad0c05
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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