Methyl iodide → HCID 66669007, compound

HRID 1617722Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25][CH3:26])=[O:24])=[C:21]([F:29])[CH:20]=1)[CH2:9][C:10](=[O:18])[C:11]1[CH:16]=[CH:15][C:14](=[O:17])[NH:13][CH:12]=1.IC.[C:32](=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25][CH3:26])=[O:24])=[C:21]([F:29])[CH:20]=1)[CH2:9][C:10]([C:11]1[CH:16]=[CH:15][C:14](=[O:17])[N:13]([CH3:32])[CH:12]=1)=[O:18]

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 11430Potassium Carbonate

HCID 66666103HCID 66666103, compound

Product 1

HCID 66669007HCID 66669007, compound

Procedure

In analogy to example 161, step 1, methyl 4-(1-(2-chlorophenyl)-3-oxo-3-(6-oxo-1,6-dihydropyridin-3-yl)propyl)-2-fluorobenzoate was reacted with iodomethane in the presence of potassium carbonate to give the title compound as an off-white foam, MS (ESI+): m/z=428.2 [M+H]+.

Sources & evidence

ORD record: ord-8d04acc81d3a4fdc933581d5c781a61a
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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