HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-5-(3-(4-Bromophenyl)-3-o-tolylpropanoyl)pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolylpropan-1-one | HCID 67015570 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-5-(3-(4-Bromophenyl)-3-o-tolylpropanoyl)pyridin-2(1H)-one | HCID 67015732 | — |
Reaction Steps
In analogy to example 162, step 2, (R)-3-(4-bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolyl-propan-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as a colorless solid, MS (ESI+): m/z=396.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-24445c7dc0da4b57b7503566c0659214 |
| Source note | uspto-grants-2014_07 |