Hydrochloric Acid → (R)-5-(3-(4-Bromophenyl)-3-o-tolylpropanoyl)pyridin-2(1H)-one

HRID 1617737노트

반응식

HRID 1617737 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9][C:10]([C:12]2[CH:13]=[N:14][C:15]([O:18]C)=[CH:16][CH:17]=2)=[O:11])=[CH:4][CH:3]=1.Cl>O1CCOCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[CH3:26])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15](=[O:18])[NH:14][CH:13]=2)=[O:11])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67015570(R)-3-(4-Bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolylpropan-1-one

생성물 1

HCID 67015732(R)-5-(3-(4-Bromophenyl)-3-o-tolylpropanoyl)pyridin-2(1H)-one

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

In analogy to example 162, step 2, (R)-3-(4-bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolyl-propan-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as a colorless solid, MS (ESI+): m/z=396.0 [M+H]+.

출처 및 근거

ORD 기록
ord-24445c7dc0da4b57b7503566c0659214
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765730B2

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