反应详情

温度

130 °C

To a solution of (R)-3-(4-bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one (example 142, step 2, 100 mg) in methanol (1.5 mL) and ethyl acetate (1.5 mL) were added [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichloromethane adduct (10 mg), triethylamine (53.3 μL) at room temperature. The reaction mixture was stirred at 130° C. for 20 h under a carbon monoxide atmosphere (70 bar). A saturated aq. solution of ammonium chloride was added, the phases were separated and the inorganic one was extracted with ethyl acetate (2×). The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by flash chromatography on silica gel (ethyl acetate/n-heptane 0:1 to 1:0) to yield the title compound as a colourless oil (95 mg, 87%), MS (ESI+): m/z=374.1 ([M+H]+).

1. customthe phases were separated
2. extractionthe inorganic one was extracted with ethyl acetate (2×)
3. washThe combined organic layers were washed with brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customThe crude product was purified by flash chromatography on silica gel (ethyl acetate/n-heptane 0:1 to 1:0)