HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → HCID 136367980, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 136166999 | HCID 136166999 | — |
| Reactant | HCID 178501210 | HCID 178501210 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 136367980 | HCID 136367980 | — |
Reaction Steps
In analogy to example 207, step 2, 4-[(R)-3-[(E)-hydroxyimino]-3-(2-methyl-pyridin-4-yl)-1-o-tolyl-propyl]-benzoic acid (example 272) was coupled with trans-methyl 4-amino-cyclohexanecarboxylate hydrochloride using benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate in tetrahydrofuran to give the title compound as a light yellow viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-27526915d7ab4b7f856017c84aba44d1 |
| Source note | uspto-grants-2014_07 |