4-Carboxyphenylboronic Acid → 4'-[(R)-2-(Methoxy-methyl-carbamoyl)-1-o-tolyl-ethyl]-biphenyl-4-carboxylic acid

HRID 1617822ノート

反応式

HRID 1617822 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[CH2:9][C:10]([N:12]([O:14][CH3:15])[CH3:13])=[O:11])=[CH:4][CH:3]=1.B([C:26]1[CH:34]=[CH:33][C:29]([C:30]([OH:32])=[O:31])=[CH:28][CH:27]=1)(O)O>>[CH3:15][O:14][N:12]([CH3:13])[C:10]([CH2:9][C@H:8]([C:5]1[CH:6]=[CH:7][C:2]([C:26]2[CH:34]=[CH:33][C:29]([C:30]([OH:32])=[O:31])=[CH:28][CH:27]=2)=[CH:3][CH:4]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH3:22])=[O:11]

参加物

3

反応物 2

HCID 3121834-Carboxyphenylboronic AcidHCID 71813344(R)-3-(4-Bromophenyl)-N-methoxy-N-methyl-3-o-tolylpropanamide

生成物 1

HCID 866610084'-[(R)-2-(Methoxy-methyl-carbamoyl)-1-o-tolyl-ethyl]-biphenyl-4-carboxylic acid

実験手順

In analogy to example 74, step 6, from (R)-3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide (example 142, step 1) and 4-boronobenzoic acid was prepared the title compound as a light brown foam, MS (ESI+): m/z=404.2 [M+H]+.

出典と根拠

ORDレコード
ord-cb193427e1494976b2f35e5123b99343
出典データセット
uspto-grants-2014_07
特許番号
US08765730B2

反応ノート

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