HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 5-[(E)-C-[2-(4-chloro-2-methylphenyl)-2-[3-fluoro-4-(2-hydroxyethoxy)phenyl]ethyl]-N-hydroxycarbonimidoyl]-1-methylpyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-{3-(4-Chloro-2-methyl-phenyl)-3-[3-fluoro-4-(2-hydroxy-ethoxy)-phenyl]-propionyl}-1-methyl-1H-pyridin-2-one | HCID 67015595 | — |
| Product | 5-[(E)-C-[2-(4-chloro-2-methylphenyl)-2-[3-fluoro-4-(2-hydroxyethoxy)phenyl]ethyl]-N-hydroxycarbonimidoyl]-1-methylpyridin-2-one | HCID 58043204 | — |
Reaction Steps
In analogy to example 151, step 3, 5-{3-(4-chloro-2-methyl-phenyl)-3-[3-fluoro-4-(2-hydroxy-ethoxy)-phenyl]-propionyl}-1-methyl-1H-pyridin-2-one was reacted with hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate to give the title compound as a colourless solid, MS (ESI+): m/z=459.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-675f6e52067c4b1aaf4dc7637e4d1f5c |
| Source note | uspto-grants-2014_07 |