HRID1617915

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID516892

Sodium Bicarbonate

CHNaO3

结构：CC1(C)OB(c2ccc(S(N)(=O)=O)cc2)OC1(C)C

HCID16414190

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide

C12H18BNO4S

结构：Cc1cc(Cl)ccc1/C=C/C(=O)c1ccc(=O)n(C)c1

HCID66668986

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(Cl)ccc1C(CC(=O)c1ccc(=O)n(C)c1)c1ccc(S(N)(=O)=O)cc1

HCID67015727

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

$结构：C1=C\CC/C=C\CC/1.C1=C\CC/C=C\CC/1.[Cl-].[Cl-].[Rh].[Rh]$

催化剂HCID6436379

未命名化合物

溶剂HCID962

Water

H2O

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

In analogy to example 203, step 1, 5-[(E)-3-(4-chloro-2-methyl-phenyl)-acryloyl]-1-methyl-1H-pyridin-2-one (example 323, step 3) was reacted with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide in the presence of chloro(1,5-cyclooctadiene)rhodium(I) dimer and sodium hydrogencarbonate in 1,4-dioxane and water at 60° C. to give the title compound as a colourless solid, MS (ESI+): m/z=445.3 [M+H]+.