HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(3-(4-chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)pyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(4-Chloro-2-methylphenyl)-1-(6-methoxypyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)propan-1-one | HCID 67015743 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(3-(4-chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)pyridin-2(1H)-one | HCID 67015754 | — |
Reaction Steps
In analogy to example 162, step 2, 3-(4-chloro-2-methylphenyl)-1-(6-methoxypyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)propan-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as an off-white solid, MS (ESI+): m/z=430.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765730B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-6cff413855f145b79d6285500dd5747d |
| Source note | uspto-grants-2014_07 |