Hydrochloric Acid → 5-(3-(4-chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)pyridin-2(1H)-one

HRID 1617917Notes

Reaction equation

HRID 1617917 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][CH:21]=2)[CH2:9][C:10]([C:12]2[CH:13]=[N:14][C:15]([O:18]C)=[CH:16][CH:17]=2)=[O:11])=[C:4]([CH3:30])[CH:3]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:21]=[CH:22][C:23]([S:26]([CH3:29])(=[O:27])=[O:28])=[CH:24][CH:25]=2)[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15](=[O:18])[NH:14][CH:13]=2)=[O:11])=[C:4]([CH3:30])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 670157433-(4-Chloro-2-methylphenyl)-1-(6-methoxypyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)propan-1-one

Product 1

HCID 670157545-(3-(4-chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)pyridin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to example 162, step 2, 3-(4-chloro-2-methylphenyl)-1-(6-methoxypyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)propan-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as an off-white solid, MS (ESI+): m/z=430.2 [M+H]+.

Sources & evidence

ORD record
ord-6cff413855f145b79d6285500dd5747d
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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