HRID1617918

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID123532

1-Bromo-3,6-dioxaheptane

C5H11BrO2

结构：Cc1cc(Cl)ccc1C(CC(=O)c1ccc(=O)[nH]c1)c1ccc(S(C)(=O)=O)cc1

HCID67015754

未命名化合物

PRODUCTS

生成物

结构：COCCOCCn1cc(C(=O)CC(c2ccc(S(C)(=O)=O)cc2)c2ccc(Cl)cc2C)ccc1=O

HCID66668760

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID67553

Tetrabutylammonium Iodide

C16H36IN

PROCEDURE

实验过程

In analogy to example 161, step 1, 5-(3-(4-chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)pyridin-2(1H)-one was reacted with 1-bromo-2-(2-methoxyethoxy)ethane in the presence of potassium carbonate and a catalytic amount of tetrabutylammonium iodide to give the title compound as a light brown oil, MS (ESI+): m/z=532.2 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-18a5ba5985e24649b859c9e1bfff9bb7
来源数据集: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08765730B2
来源说明: uspto-grants-2014_07

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][CH:20]=2)[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][CH:17]=2)=[O:11])=[C:4]([CH3:29])[CH:3]=1.Br[CH2:31][CH2:32][O:33][CH2:34][CH2:35][O:36][CH3:37].C(=O)([O-])[O-].[K+].[K+]>[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:20]=[CH:21][C:22]([S:25]([CH3:28])(=[O:26])=[O:27])=[CH:23][CH:24]=2)[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[N:16]([CH2:31][CH2:32][O:33][CH2:34][CH2:35][O:36][CH3:37])[CH:17]=2)=[O:11])=[C:4]([CH3:29])[CH:3]=1