Iodoacetamide → 2-(5-(3-(4-Chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)-2-oxopyridin-1(2H)-yl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	Iodoacetamide	HCID 3727	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	5-(3-(4-chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)pyridin-2(1H)-one	HCID 67015754	—
Product	2-(5-(3-(4-Chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)-2-oxopyridin-1(2H)-yl)acetamide	HCID 66666953	—

Reaction Steps

In analogy to example 161, step 1, 5-(3-(4-chloro-2-methylphenyl)-3-(4-(methylsulfonyl)phenyl)propanoyl)pyridin-2(1H)-one (example 339, step 2) was reacted with 2-iodoacetamide in the presence of potassium carbonate to give the title compound as a light yellow solid, MS (ESI+): m/z=487.3 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08765730B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-20c018393d54485dbb320ad0b96b2965
Source note	uspto-grants-2014_07