Hydrochloric Acid → HCID 66668187, compound

HRID 1617946Notes

Reaction equation

HRID 1617946 reaction equation
[F:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([C:13]2[CH:14]=[N:15][C:16]([O:19]C)=[CH:17][CH:18]=2)=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1.Cl>O1CCOCC1>[F:8][C:6]1[CH:5]=[C:4](/[CH:9]=[CH:10]/[C:11]([C:13]2[CH:18]=[CH:17][C:16](=[O:19])[NH:15][CH:14]=2)=[O:12])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66668674HCID 66668674, compound

Product 1

HCID 66668187HCID 66668187, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to example 162, step 2, (E)-3-(3,5-difluorophenyl)-1-(6-methoxypyridin-3-yl)prop-2-en-1-one was reacted with concentrated aqueous HCl in 1,4-dioxane to give the title compound as a colourless solid, MS (ESI+): m/z=262.1 [M+H]+.

Sources & evidence

ORD record
ord-cf119f828536452ba50e938c0f11714f
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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