Sodium Bicarbonate → HCID 58043214, compound

HRID 1618044Notes

Reaction equation

Cl.[NH2:2][OH:3].[CH3:4][N:5]1[C:10](=[O:11])[CH:9]=[CH:8][C:7]([C:12](=O)[CH2:13][C@H:14]([C:22]2[CH:27]=[CH:26][C:25]([CH2:28][C:29]([OH:31])=[O:30])=[CH:24][CH:23]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])=[CH:6]1.C(=O)([O-])O.[Na+]>>[OH:3]/[N:2]=[C:12](/[C:7]1[CH:8]=[CH:9][C:10](=[O:11])[N:5]([CH3:4])[CH:6]=1)\[CH2:13][C@H:14]([C:22]1[CH:23]=[CH:24][C:25]([CH2:28][C:29]([OH:31])=[O:30])=[CH:26][CH:27]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21]

Participants

Reactant 2

HCID 516892Sodium Bicarbonate

HCID 67015769HCID 67015769, compound

Product 1

HCID 58043214HCID 58043214, compound

Procedure

In analogy to example 1, step 2, from and (R)-2-(4-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)phenyl)acetic acid hydroxylamine hydrochloride in the presence of sodium hydrogencarbonate was prepared the title compound as an off-white solid, MS (ESI+): m/z=405.4 [M+H]+.

Sources & evidence

ORD record: ord-846430ecdb7348ffa3d1bebfb0e7c9c1
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

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