4-(Benzo[d]oxazol-2-yl)phenol → Benzoxazole
Reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1C1C=CC(O)=CC=1>O1CCCC1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 30 °C
Procedure
Into a stirred solution of 0.5 g (2.4 mmol) of 4-(2-Benzoxazolyl)-phenol prepared as described in example 1 of in 10 ml of tetrahydrofurane and a few drops of dibutyltindilaurate catalyst, was added 0.6 g (2.52 mmol) of ICTEOS under nitrogen atmosphere. The mixture was stirred for 18 h at 30° C. After removal of the solvent, the product was precipitated with hexane, filtrated and dried to yield 0.99 g (90%) of (4-(3-(triethoxysilyl)propyl]-amino]carbonyl]oxy])phenyl)-benzoxazole. M.p. 141-142° C.; UV (ethanol) 304 nm (24′630).
Workup
- additionwas added 0.6 g (2.52 mmol) of ICTEOS under nitrogen atmosphere
- customAfter removal of the solvent
- customthe product was precipitated with hexane
- filtrationfiltrated
- customdried
Sources & evidence
- ORD record
- ord-c0248f25e20141f7bd3a6bb4f9ecc2ec
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08765967B2
Reaction notes
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