1,3-Dibromobenzene → HCID 66629554, compound

HRID 1618430Notes

Reaction equation

HRID 1618430 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[CH:3]=1.[C:9]([C:11]([OH:18])([CH2:15][CH2:16][CH3:17])[CH2:12][CH2:13][CH3:14])#[CH:10]>>[Br:8][C:4]1[CH:3]=[C:2]([C:10]#[C:9][C:11]([OH:18])([CH2:15][CH2:16][CH3:17])[CH2:12][CH2:13][CH3:14])[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 79271,3-DibromobenzeneHCID 123838984-Ethynylheptan-4-ol

Product 1

HCID 66629554HCID 66629554, compound

Procedure

1,3-Dibromobenzene was coupled with alkynol 20 following the procedure described in Example 10 to give 4-((3-bromophenyl)ethynyl)heptan-4-ol as a yellow liquid. Yield (4.2 g, 65%): 1H NMR (400 MHz, DMSO-d6) δ 7.56-7.52 (m, 2H), 7.36 (dt, J=8.0, 1.2 Hz, 1H), 7.30 (t, J=8.0 Hz, 1H), 5.18 (s, 1H), 1.60-1.40 (m, 8H), 0.89 (t, J=7.2 Hz, 6H).

Sources & evidence

ORD record
ord-2374c819dbf1455abff718d26866ee48
Source dataset
uspto-grants-2014_07
Patent number
US08766007B2

Reaction notes

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