2-Bromoethanol → HCID 57608491, compound

HRID 1618441Notes

Reaction equation

HRID 1618441 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([SH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][CH2:11][OH:12]>>[Br:1][C:2]1[CH:3]=[C:4]([S:8][CH2:10][CH2:11][OH:12])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 108982-BromoethanolHCID 80597m-Bromobenzenethiol

Product 1

HCID 57608491HCID 57608491, compound

Procedure

Alkylation of 3-bromobenzenethiol with 2-bromoethanol according to the method used in Example 18, gave 2-(3-bromophenylthio)ethanol (125) as a yellow oil without purification. Yield (3.6 g, 97%): 1H NMR (400 MHz, CDCl3) δ 7.49 (t, J=2.0 Hz, 1H), 7.31 (ddd, J=0.8, 1.6, 8.0 Hz, 1H), 7.27 (ddd, J=0.8, 1.6, 8.0 Hz, 1H), 7.13 (t, J=7.6 Hz, 1H), 3.75 (t, J=6.4 Hz, 2H), 3.10 (t, J=6.4 Hz, 2H), 2.18 (brs, 1H).

Sources & evidence

ORD record
ord-736dae794cf34d56bc26cc625d22417d
Source dataset
uspto-grants-2014_07
Patent number
US08766007B2

Reaction notes

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