Hydrochloric Acid → 1,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate

Participants

Reaction Steps

Prepared according to procedure G using potassium carbonate (94.23 g, 681.8 mmol), dimethyl malonate (39.1 mL, 340.9 mmol) and 4-bromo-1-fluoro-2-nitrobenzene (28 mL, 227.27 mmol) in DMF (227 mL). After pouring over 200 mL of 2N aqueous HCl the precipitate was collected by filtration and washed with water (4 L) to give dimethyl 2-(4-bromo-2-nitrophenyl)malonate. Mass Spectrum (ESI) m/e=332 [(M+1) (79Br)] and 334 [(M+1) (81Br)].

Provenance & Evidence