反应详情

Prepared according to procedure F using 2,4-dichloro-7-fluoro-3-methylquinoline (500 mg, 2.17 mmol), 3-cyanophenylboronic acid (319 mg, 2.17 mmol), Pd(PPh3)4 (251 mg, 0.22 mmol) in toluene:water (10 mL:4 mL) and heating at reflux overnight. After purification, 3-(4-chloro-7-fluoro-3-methylquinolin-2-yl)benzonitrile was obtained as a white solid.

1. customPrepared
2. temperatureat reflux overnight
3. customAfter purification