HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(4-Chloro-7-fluoro-3-methylquinolin-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Cyanophenylboronic acid | HCID 2734325 | — |
| Reactant | 2,4-Dichloro-7-fluoro-3-methylquinoline | HCID 59631108 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(4-Chloro-7-fluoro-3-methylquinolin-2-yl)benzonitrile | HCID 67285543 | — |
Reaction Steps
Prepared according to procedure F using 2,4-dichloro-7-fluoro-3-methylquinoline (500 mg, 2.17 mmol), 3-cyanophenylboronic acid (319 mg, 2.17 mmol), Pd(PPh3)4 (251 mg, 0.22 mmol) in toluene:water (10 mL:4 mL) and heating at reflux overnight. After purification, 3-(4-chloro-7-fluoro-3-methylquinolin-2-yl)benzonitrile was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765940B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-4709cb7fb0804fe599b700f1a1fcc785 |
| Source note | uspto-grants-2014_07 |