Sodium Hydroxide → HCID 67285416, compound

HRID 1618496Notes

Reaction equation

HRID 1618496 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:17])[CH:10]([CH3:16])[C:11]([O:13]CC)=[O:12].[OH-].[Na+]>C1COCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:17])[CH:10]([CH3:16])[C:11]([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67284369HCID 67284369, compound

Product 1

HCID 67285416HCID 67285416, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared according to procedure B using ethyl 3-(2-fluorophenylamino)-2-methyl-3-oxopropanoate (15.0 g, 62.7 mmol) and NaOH (3.26 g, 81.5 mmol) in THF (60 mL) to give 3-(2-fluorophenylamino)-2-methyl-3-oxopropanoic acid as a white solid. Mass Spectrum (ESI) m/e=212.1 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-14b30496a92648bf90b60eab54d97a9a
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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