反应详情

Prepared according to procedure E using 2,4-dichloro-7-fluoro-3-methylquinoline (500 mg, 2.17 mmol), palladium tetrakistriphenylphosphine (0.251 mg, 0.22 mmol) and 4-tributylstannylpyridine (800 mg, 4.35 mmol) in toluene (15 mL). After purification 4-chloro-7-fluoro-3-methyl-2-(pyridin-4-yl)quinoline was obtained as a white solid.

1. customPrepared
2. customAfter purification 4-chloro-7-fluoro-3-methyl-2-(pyridin-4-yl)quinoline
3. customwas obtained as a white solid