HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Tri-n-butylstannyl)pyridine → 4-Chloro-7-fluoro-3-methyl-2-(pyridin-4-yl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Tri-n-butylstannyl)pyridine | HCID 2737318 | — |
| Reactant | 2,4-Dichloro-7-fluoro-3-methylquinoline | HCID 59631108 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Chloro-7-fluoro-3-methyl-2-(pyridin-4-yl)quinoline | HCID 67284736 | — |
Reaction Steps
Prepared according to procedure E using 2,4-dichloro-7-fluoro-3-methylquinoline (500 mg, 2.17 mmol), palladium tetrakistriphenylphosphine (0.251 mg, 0.22 mmol) and 4-tributylstannylpyridine (800 mg, 4.35 mmol) in toluene (15 mL). After purification 4-chloro-7-fluoro-3-methyl-2-(pyridin-4-yl)quinoline was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765940B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-7f30bd90b10a49378cffe76f770c04d7 |
| Source note | uspto-grants-2014_07 |