反应详情

Prepared according to procedure H using dimethyl 2-(5-bromo-3-nitropyridin-2-yl)malonate (35 g, 105 mmol), lithium chloride (22.27 g, 525 mmol) and water (50 mL) and heating at reflux for 24 h. After purification methyl 2-(5-bromo-3-nitropyridin-2-yl)acetate was obtained as brown oil. Mass Spectrum (ESI) m/e=275 [(M+1) (79Br)] and 277 [(M+1) (81Br)].

1. customPrepared
2. temperatureheating
3. temperatureat reflux for 24 h
4. customAfter purification methyl 2-(5-bromo-3-nitropyridin-2-yl)acetate
5. customwas obtained as brown oil