HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Chloride → Methyl 2-(5-bromo-3-nitropyridin-2-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | Dimethyl 2-(5-bromo-3-nitropyridin-2-YL)malonate | HCID 53217420 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 2-(5-bromo-3-nitropyridin-2-yl)acetate | HCID 67284396 | — |
Reaction Steps
Prepared according to procedure H using dimethyl 2-(5-bromo-3-nitropyridin-2-yl)malonate (35 g, 105 mmol), lithium chloride (22.27 g, 525 mmol) and water (50 mL) and heating at reflux for 24 h. After purification methyl 2-(5-bromo-3-nitropyridin-2-yl)acetate was obtained as brown oil. Mass Spectrum (ESI) m/e=275 [(M+1) (79Br)] and 277 [(M+1) (81Br)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765940B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-85614c93c94a4551931fdc6ba25b9cb8 |
| Source note | uspto-grants-2014_07 |