Sodium bis(2-methoxyethoxy)aluminiumhydride → 6'-Bromo-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo[3,2-b]pyridine]

Participants

Role	Name	HCID	Charge
Reactant	Sodium bis(2-methoxyethoxy)aluminiumhydride	HCID 21584525	—
Reactant	6'-Bromo-1',2'-dihydrospiro[oxane-4,3'-pyrrolo[3,2-b]pyridine]-2'-one	HCID 66954310	—
Solvent	Toluene	HCID 1140	—
Product	6'-Bromo-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo[3,2-b]pyridine]	HCID 67284560	—

Reaction Steps

Prepared according to procedure K using 6′-bromo-2,3,5,6-tetrahydrospiro[pyran-4,3′-pyrrolo[3,2-b]pyridin]-2′(1′H)-one (138 mg, 0.487 mmol) and sodium bis(2-methoxyethoxy)aluminium hydride (304 μL, 1.560 mmol) in toluene (3 mL). After purification 6′-bromo-1′,2,2′,3,5,6-hexahydrospiro[pyran-4,3′-pyrrolo[3,2-b]pyridine] was obtained as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08765940B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-07d2e44e17754d0dacd89e2043f465e6
Source note	uspto-grants-2014_07