HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1618534Generated: November 1, 2026
Sodium Carbonate → 4-Chloro-2-(3,5-dimethylphenyl)-7-fluoro-3-methylquinoline
https://huagongshe.com/reaction/1618534
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3,5-Dimethylphenylboronic acid | HCID 2734349 | — |
| Reactant | 2,4-Dichloro-7-fluoro-3-methylquinoline | HCID 59631108 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene water | HCID 22272177 | — |
| Product | 4-Chloro-2-(3,5-dimethylphenyl)-7-fluoro-3-methylquinoline | HCID 67284517 | — |
Reaction Steps
Prepared according to procedure F using 2,4-dichloro-7-fluoro-3-methylquinoline (500 mg, 2.173 mmol), 3,5-dimethylbenzeneboronic acid (326 mg, 2.173 mmol), sodium carbonate (1.15 g, 10.87 mmol) and Pd(PPh3)4 (251 mg, 0.217 mmol) in toluene/water (4 mL:1 mL) and heating in the microwave for 90 min at 120° C. After purification 4-chloro-2-(3,5-dimethylphenyl)-7-fluoro-3-methylquinoline was obtained as a white solid. Mass Spectrum (ESI) m/e=300 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08765940B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-4cc10791e2a64c8f8c78111b607d5696 |
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| Source note | uspto-grants-2014_07 |
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