Sodium Hydroxide → HCID 59631100, compound

HRID 1618557Notes

Reaction equation

HRID 1618557 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:18])[CH:11]([CH3:17])[C:12]([O:14]CC)=[O:13])[CH:5]=[C:6]([F:8])[CH:7]=1.[OH-].[Na+]>C1COCC1.O>[F:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:18])[CH:11]([CH3:17])[C:12]([OH:14])=[O:13])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 59631396HCID 59631396, compound

Product 1

HCID 59631100HCID 59631100, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Prepared according to procedure B using ethyl 3-(3,5-difluorophenylamino)-2-methyl-3-oxopropanoate (11.4 g, 44.3 mmol) (described herein) in THF (40 mL), and sodium hydroxide (1.22 g, 53.2 mmol) in water (10 mL). The reaction was stirred at rt for 2 h, affording 3-(3,5-difluorophenylamino)-2-methyl-3-oxopropanoic acid. Mass Spectrum (ESI) m/e=230 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-01f07dfb16334bba9f143da979aa7fb3
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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