Ethyl 2-methylacetoacetate → HCID 178426077, compound

HRID 1618580Notes

Reaction equation

HRID 1618580 reaction equation
[Cl:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:3]=1[NH2:4].C([O:12][C:13](=O)[CH:14]([CH3:18])[C:15]([CH3:17])=O)C>>[Cl:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]2[C:3]=1[N:4]=[C:15]([CH3:17])[C:14]([CH3:18])=[C:13]2[OH:12]

Participants

3

Reactant 2

HCID 701Ethyl 2-methylacetoacetateHCID 120072-Chloro-p-toluidine

Product 1

HCID 178426077HCID 178426077, compound

Procedure

Prepared according to procedure R using 2-chloro-4-methyl-aniline (2.0 mL, 16.3 mmol), ethyl-2-methyl-acetoacetate (4.6 mL, 32.5 mmol), and PPA (8.12 g, 81.2 mmol) to afford 8-chloro-2,3,6-trimethylquinolin-4-ol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7239a892cfd243dbaeba184879f9810f
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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