Phosphorus oxychloride → HCID 63409230, compound

HRID 1618581Notes

Reaction equation

HRID 1618581 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH3:15])[CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[C:8]([CH3:13])=[C:7]2O.O=P(Cl)(Cl)[Cl:18]>>[Cl:18][C:7]1[C:6]2[C:11](=[C:2]([Cl:1])[CH:3]=[C:4]([CH3:15])[CH:5]=2)[N:10]=[C:9]([CH3:12])[C:8]=1[CH3:13]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178426077HCID 178426077, compound

Product 1

HCID 63409230HCID 63409230, compound

Procedure

Prepared according to procedure S using 8-chloro-2,3,6-trimethylquinolin-4-ol (1.56 g, 7.0 mmol) and POCl3 (8.0 mL, 85.8 mmol) to afford 4,8-dichloro-2,3,6-trimethylquinoline.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-79798d9c83a644d09a2f02733b96c0c1
Source dataset
uspto-grants-2014_07
Patent number
US08765940B2

Reaction notes

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